Automated fabrication of human skin substitutes: inherent advantages and fundamental challenges

Boyce S| Journal of 3D Printing in Medicine, 5(3) (2021) Keywords: additive manufacturing • biofabrication • CAD/CAM • cell viability • tissue engineering Manually fabricated human skin substitutes (HSSs) have been demonstrated to provide reductions in morbidity and mortality after both acute skin loss, for example through burns, and chronic wounds, such as diabetic ulcers. In order to produce HSSs, automated fabrication may use extrusion of cell and polymer mixtures applied in laminations, laser pulse transfer for micropatterning or vascular ingrowth by preimplantation before transferal to the target site. However, due to the multiple cell types and micropatterning within the polymer scaffold, the resulting HSS…

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